Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0468

Protein Name

Aquaporin-1

Gene Name

Aqp1; Chip28

Organism

Rattus norvegicus (Rat)

Length

269 amino acids

AlphaFoldDB

AF-P29975-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex;a multiprotein complex involved in the stability and shape of the erythrocyte membrane.

Sequence

MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVASAILSGITSSLLENSLGRNDLARGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGSALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 56: "Substrate discrimination"; SITE 180: "Substrate discrimination"; SITE 189: "Hg(2+)-sensitive residue"; SITE 195: "Substrate discrimination";

Disease

sepsis; endotoxemia-induced

Location

Erythrocytes and renal tubules

DOI ID

10.1016/0006-291x(92)91368-z; 10.1007/bf00374565; 10.1083/jcb.120.2.359; 10.1161/01.res.73.1.193; 10.1101/gr.2596504; 10.1038/ncomms1871

RefSeq

NP_036910.1